The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosis
RA Shimkets, RP Lifton, CM Canessa - Journal of Biological Chemistry, 1997 - ASBMB
Activity of the epithelial sodium channel (ENaC) is a key determinant of sodium homeostasis
and blood pressure. Liddle's syndrome, an inherited form of hypertension, is caused by
mutations that delete or alter PY domains in the carboxyl termini of β or γ ENaC subunits,
leading to increased channel activity. In this study we investigated the mechanism of this
effect by analysis of wild-type and mutant ENaC activity in Xenopus oocytes. By inhibiting
insertion of new channels into the plasma membrane with brefeldin A, we demonstrate that …
and blood pressure. Liddle's syndrome, an inherited form of hypertension, is caused by
mutations that delete or alter PY domains in the carboxyl termini of β or γ ENaC subunits,
leading to increased channel activity. In this study we investigated the mechanism of this
effect by analysis of wild-type and mutant ENaC activity in Xenopus oocytes. By inhibiting
insertion of new channels into the plasma membrane with brefeldin A, we demonstrate that …
