[HTML][HTML] Phospholamban inhibitory function is activated by depolymerization
Y Kimura, K Kurzydlowski, M Tada… - Journal of Biological …, 1997 - ASBMB
Phospholamban (PLN), a homopentameric, integral membrane protein, reversibly inhibits
cardiac sarcoplasmic reticulum Ca 2+-ATPase (SERCA2a) activity through intramembrane
interactions. Here, alanine-scanning mutagenesis of the PLN transmembrane sequence
was used to identify two functional domains on opposite faces of the transmembrane helix.
Mutations in one face diminish inhibitory interactions with transmembrane sequences of
SERCA2a, but have relatively little effect on the pentameric state, while mutations in the …
cardiac sarcoplasmic reticulum Ca 2+-ATPase (SERCA2a) activity through intramembrane
interactions. Here, alanine-scanning mutagenesis of the PLN transmembrane sequence
was used to identify two functional domains on opposite faces of the transmembrane helix.
Mutations in one face diminish inhibitory interactions with transmembrane sequences of
SERCA2a, but have relatively little effect on the pentameric state, while mutations in the …
