Enhanced glycogen synthase kinase-3β activity mediates hypoxia-induced apoptosis of vascular smooth muscle cells and is prevented by glucose transport and …
RD Loberg, E Vesely, FC Brosius - Journal of Biological Chemistry, 2002 - ASBMB
Hypoxia triggers apoptosis in a number of different cell types largely through a mitochondrial
cell death pathway, which can be abrogated for the most part by enhanced glucose
metabolism. The purpose of the current study was to identify intracellular signaling
mechanisms that mediate hypoxia-induced apoptosis and are regulated by glucose
metabolism. Hypoxia-induced apoptosis in vascular smooth muscle cells and COS-7 cells
was accompanied by a significant reduction in Akt and glycogen synthase kinase-3 (GSK-3) …
cell death pathway, which can be abrogated for the most part by enhanced glucose
metabolism. The purpose of the current study was to identify intracellular signaling
mechanisms that mediate hypoxia-induced apoptosis and are regulated by glucose
metabolism. Hypoxia-induced apoptosis in vascular smooth muscle cells and COS-7 cells
was accompanied by a significant reduction in Akt and glycogen synthase kinase-3 (GSK-3) …
