Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression
MB Bansal, K Kovalovich, R Gupta, W Li, A Agarwal… - Journal of …, 2005 - Elsevier
BACKGROUND/AIMS: Interleukin-6 stimulates liver regeneration and promotes
hepatoprotection following experimental liver injury, but underlying mechanisms have not
been fully characterized. Because studies suggest matrix metalloproteinase-2 (MMP-2) may
promote liver injury, we examined whether IL-6 exerted its protective effects via regulation of
MMP-2. METHODS: MMP-2 was analyzed in livers of IL-6−/− and IL-6+/+ mice following
CCl4 administration. IL-6−/− mice were pretreated with IL-6 and liver histology and MMP-2 …
hepatoprotection following experimental liver injury, but underlying mechanisms have not
been fully characterized. Because studies suggest matrix metalloproteinase-2 (MMP-2) may
promote liver injury, we examined whether IL-6 exerted its protective effects via regulation of
MMP-2. METHODS: MMP-2 was analyzed in livers of IL-6−/− and IL-6+/+ mice following
CCl4 administration. IL-6−/− mice were pretreated with IL-6 and liver histology and MMP-2 …
