Fatty acids, triglycerides, and glucose metabolism: recent insights from knockout mice
HC Chen, RV Farese Jr - Current Opinion in Clinical Nutrition & …, 2002 - journals.lww.com
HC Chen, RV Farese Jr
Current Opinion in Clinical Nutrition & Metabolic Care, 2002•journals.lww.comThe inactivation of enzymes in the anabolic process of fatty acid uptake and storage is more
likely to enhance tissue glucose disposal or insulin secretion, whereas disruptions in the
catabolic process tend to impair insulin action or secretion. These findings suggest that
pharmacological inhibition of fatty acid uptake or storage may be an effective strategy for
treating insulin resistance and diabetes.
likely to enhance tissue glucose disposal or insulin secretion, whereas disruptions in the
catabolic process tend to impair insulin action or secretion. These findings suggest that
pharmacological inhibition of fatty acid uptake or storage may be an effective strategy for
treating insulin resistance and diabetes.
Summary
The inactivation of enzymes in the anabolic process of fatty acid uptake and storage is more likely to enhance tissue glucose disposal or insulin secretion, whereas disruptions in the catabolic process tend to impair insulin action or secretion. These findings suggest that pharmacological inhibition of fatty acid uptake or storage may be an effective strategy for treating insulin resistance and diabetes.
Lippincott Williams & Wilkins