G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptors (GPCRs)
activate numerous cellular signals through the combined actions of G proteins, GPCR
kinases, and arrestins. Although arrestins have traditionally been thought of as mediating
GPCR desensitization, they have now been shown to play important roles in the
internalization, trafficking, and signaling of many GPCRs. We demonstrate that in cells
devoid of arrestins, the stimulation of numerous GPCRs including the N-formyl peptide …