[HTML][HTML] Update on mechanism and catalytic regulation in the NO synthases
DJ Stuehr, J Santolini, ZQ Wang, CC Wei… - Journal of Biological …, 2004 - ASBMB
Nitric-oxide synthases (NOSs, EC 1.14. 13.39) 1 oxidize L-arginine to nitric oxide (NO) and
are interesting for several reasons. They are present in many life forms (1, 2), their gene
regulation is complex (3), they are the only flavoheme enzymes that utilize
tetrahydrobiopterin (H4B) as a redox cofactor, and their electron transfer reactions are
regulated by a Ca2-binding protein (calmodulin). In the past 5 years, crystal structures of
NOS heme (oxygenase) domains and bacterial NOS-like proteins have shown how Arg …
are interesting for several reasons. They are present in many life forms (1, 2), their gene
regulation is complex (3), they are the only flavoheme enzymes that utilize
tetrahydrobiopterin (H4B) as a redox cofactor, and their electron transfer reactions are
regulated by a Ca2-binding protein (calmodulin). In the past 5 years, crystal structures of
NOS heme (oxygenase) domains and bacterial NOS-like proteins have shown how Arg …
