Portal glucose infusion exerts an incretin effect associated with changes in pancreatic neural activity in conscious dogs
BE Dunning, MC Moore, T Ikeda… - Metabolism …, 2002 - metabolismjournal.com
We sought to determine whether an incretin effect could be observed when glucose was
infused via the hepatic portal (Po) vein versus a peripheral (Pe) vein. Identical
hyperglycemia (155 [plusmn] 7 and 154 [plusmn] 8 mg/dL, respectively) was produced in 2
groups (n= 9 each) of conscious dogs by Po or Pe glucose infusion. During glucose infusion,
arterial plasma insulin levels increased by 28 [plusmn] 5 and 16 [plusmn] 3 [mu] U/mL in Po
and Pe, respectively (P [lt]. 05 between groups). Pancreatic insulin output increased by 10.4 …
infused via the hepatic portal (Po) vein versus a peripheral (Pe) vein. Identical
hyperglycemia (155 [plusmn] 7 and 154 [plusmn] 8 mg/dL, respectively) was produced in 2
groups (n= 9 each) of conscious dogs by Po or Pe glucose infusion. During glucose infusion,
arterial plasma insulin levels increased by 28 [plusmn] 5 and 16 [plusmn] 3 [mu] U/mL in Po
and Pe, respectively (P [lt]. 05 between groups). Pancreatic insulin output increased by 10.4 …
