Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins
E Soutoglou, G Papafotiou, N Katrakili… - Journal of Biological …, 2000 - ASBMB
Hepatocyte nuclear factor-1 (HNF-1) plays an important role in the regulation of a large
number of genes expressed in the liver, kidney, and pancreatic β-cells. In exploring the
molecular mechanism involved in HNF-1-dependent gene activation in the in vivo chromatin
context, we found that HNF-1 can physically interact with the histone acetyltransferases
(HATs) CREB-binding protein (CBP), p300/CBP-associated factor (P/CAF), Src-1, and
RAC3. The transcriptional activation potential of HNF-1 on a genome integrated promoter …
number of genes expressed in the liver, kidney, and pancreatic β-cells. In exploring the
molecular mechanism involved in HNF-1-dependent gene activation in the in vivo chromatin
context, we found that HNF-1 can physically interact with the histone acetyltransferases
(HATs) CREB-binding protein (CBP), p300/CBP-associated factor (P/CAF), Src-1, and
RAC3. The transcriptional activation potential of HNF-1 on a genome integrated promoter …
