Subcellular Localization of (Latent) Transforming Growth Factor β and the Latent Tgf–β Binding Protein in Rat Hepatocytes and Hepatic Stellate Cells
S Roth-Eichhorn, K Kühl, AM Gressner - Hepatology, 1998 - journals.lww.com
Recently, the existence of the large latent transforming growth factor β (TGF–β) complex,
consisting of TGF–β, the N–terminal part of its precursor (latency–associated peptide [LAP]),
and the latent TGF–β binding protein (LTBP), was demonstrated in rat liver parenchymal
cells (PC) and stellate cells (HSC). However, in contrast to HSC, in freshly isolated PC, no
message of these proteins is detectable. This study was performed to investigate the
subcellular distribution of the proteins forming the latent TGF–β complex in PC and HSC …
consisting of TGF–β, the N–terminal part of its precursor (latency–associated peptide [LAP]),
and the latent TGF–β binding protein (LTBP), was demonstrated in rat liver parenchymal
cells (PC) and stellate cells (HSC). However, in contrast to HSC, in freshly isolated PC, no
message of these proteins is detectable. This study was performed to investigate the
subcellular distribution of the proteins forming the latent TGF–β complex in PC and HSC …