Convergence of the NF-κB and IRF pathways in the regulation of the innate antiviral response
J Hiscott - Cytokine & growth factor reviews, 2007 - Elsevier
The type I interferon (IFN) α and β promoters have been a leading paradigm of virus-
activated transcriptional regulation for more than two decades, and have contributed
substantially to our understanding of virus-inducible gene regulation, the coordinated
activities of NF-κB and IRF transcription factors, the temporal and spatial recruitment of co-
activators to the enhanceosome, and signaling pathways that trigger the innate antiviral
response. In 2003, the ISICR Milstein Award was presented to John Hiscott of McGill …
activated transcriptional regulation for more than two decades, and have contributed
substantially to our understanding of virus-inducible gene regulation, the coordinated
activities of NF-κB and IRF transcription factors, the temporal and spatial recruitment of co-
activators to the enhanceosome, and signaling pathways that trigger the innate antiviral
response. In 2003, the ISICR Milstein Award was presented to John Hiscott of McGill …
