[HTML][HTML] Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo
The p21-activated kinase PAK1 is implicated in tumorigenesis, and efforts to inhibit PAK1
signaling as a means to induce tumor cell apoptosis are underway. However, PAK1 has also
been implicated as a positive effector of mechanisms in clonal pancreatic beta cells and
skeletal myotubes that would be crucial to maintaining glucose homeostasis in vivo. Of
relevance, human islets of Type 2 diabetic donors contained∼ 80% less PAK1 protein
compared with non-diabetics, implicating PAK1 in islet signaling/scaffolding functions …
signaling as a means to induce tumor cell apoptosis are underway. However, PAK1 has also
been implicated as a positive effector of mechanisms in clonal pancreatic beta cells and
skeletal myotubes that would be crucial to maintaining glucose homeostasis in vivo. Of
relevance, human islets of Type 2 diabetic donors contained∼ 80% less PAK1 protein
compared with non-diabetics, implicating PAK1 in islet signaling/scaffolding functions …
