Exocytosis-endocytosis coupling in the pancreatic beta cell

L Orci, F Malaisse-Lagae, M Ravazzola, M Amherdt… - Science, 1973 - science.org
L Orci, F Malaisse-Lagae, M Ravazzola, M Amherdt, AE Renold
Science, 1973science.org
The stimulation of the release of insulin by glucose is accompanied by an enhanced uptake
of cytochemically demonstrable horseradish peroxidase into endocytotic vesicles within the
beta cells. An exocytosis-endocytosis coupling might represent a mechanism by which
membrane constituents are recycled within the beta cells under conditions of increased
secretory activity.
The stimulation of the release of insulin by glucose is accompanied by an enhanced uptake of cytochemically demonstrable horseradish peroxidase into endocytotic vesicles within the beta cells. An exocytosis-endocytosis coupling might represent a mechanism by which membrane constituents are recycled within the beta cells under conditions of increased secretory activity.
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