[HTML][HTML] The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
EL Greer, PR Oskoui, MR Banko, JM Maniar… - Journal of Biological …, 2007 - ASBMB
The maintenance of homeostasis throughout an organism's life span requires constant
adaptation to changes in energy levels. The AMP-activated protein kinase (AMPK) plays a
critical role in the cellular responses to low energy levels by switching off energy-consuming
pathways and switching on energy-producing pathways. However, the transcriptional
mechanisms by which AMPK acts to adjust cellular energy levels are not entirely
characterized. Here, we find that AMPK directly regulates mammalian FOXO3, a member of …
adaptation to changes in energy levels. The AMP-activated protein kinase (AMPK) plays a
critical role in the cellular responses to low energy levels by switching off energy-consuming
pathways and switching on energy-producing pathways. However, the transcriptional
mechanisms by which AMPK acts to adjust cellular energy levels are not entirely
characterized. Here, we find that AMPK directly regulates mammalian FOXO3, a member of …