Chemokines are a family of small and secreted proteins that play pleiotropic roles in
inflammation-related pathological diseases, including cancer. Among the identified 50
human chemokines, chemokine (CC motif) ligand 2 (CCL2) is of particular importance in
cancer development since it serves as one of the key mediators of interactions between
tumor and host cells. CCL2 is produced by cancer cells and multiple different host cells
within the tumor microenvironment. CCL2 mediates tumorigenesis in many different cancer …