[PDF][PDF] The effector functions of immunoglobulins: implications for therapy
ES VV3rd, V Ghetie - Therapeutic Immunology, 1995 - docs.wardoberlab.com
The effector functions of immunoglobulins of the G class (IgGs) are essential for their
effective use if therapy. The functions that operate following complex formation with cognate
antigen involve binding to C1q (to mediate comp-lement fixation) and the Fc receptors,
FcyRI, II and III. Another class of functions that is independent of antigen binding
encompasses the transfer of antibodies across the placenta and maintaining the levels in
the serum. All effector functions of IgGs are conferred by sequences in the Fc region of …
effective use if therapy. The functions that operate following complex formation with cognate
antigen involve binding to C1q (to mediate comp-lement fixation) and the Fc receptors,
FcyRI, II and III. Another class of functions that is independent of antigen binding
encompasses the transfer of antibodies across the placenta and maintaining the levels in
the serum. All effector functions of IgGs are conferred by sequences in the Fc region of …
