[HTML][HTML] The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7
H Yoshida, H Jono, H Kai, JD Li - Journal of Biological Chemistry, 2005 - ASBMB
Toll-like receptor 2 (TLR2) plays an important role in host defense against bacterial
pathogens. Activation of TLR2 signaling not only induces the activation of innate immunity
and instructs the development of the acquired immunity but also leads to the detrimental
inflammatory responses in inflammatory and infectious diseases. To avoid detrimental
inflammatory responses, TLR2 signaling must be tightly regulated. In contrast to the relative
known positive regulation of TLR2 signaling, its negative regulation, however, is largely …
pathogens. Activation of TLR2 signaling not only induces the activation of innate immunity
and instructs the development of the acquired immunity but also leads to the detrimental
inflammatory responses in inflammatory and infectious diseases. To avoid detrimental
inflammatory responses, TLR2 signaling must be tightly regulated. In contrast to the relative
known positive regulation of TLR2 signaling, its negative regulation, however, is largely …