[HTML][HTML] Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 …
H Nakashima, T Nguyen, WF Goins… - Journal of Biological …, 2015 - ASBMB
The ubiquitin-like interferon (IFN)-stimulated gene 15 (ISG15) and its specific E1, E2, and E3
enzymes are transcriptionally induced by type I IFNs. ISG15 conjugates newly synthesized
proteins. ISG15 linkage to proteins appears to be an important downstream IFN signaling
event that discriminates cellular and pathogenic proteins synthesized during IFN stimulation
from existing proteins. This eliminates potentially pathogenic proteins as the cell attempts to
return to normal homeostasis after IFN" stressed" conditions. However, the molecular events …
enzymes are transcriptionally induced by type I IFNs. ISG15 conjugates newly synthesized
proteins. ISG15 linkage to proteins appears to be an important downstream IFN signaling
event that discriminates cellular and pathogenic proteins synthesized during IFN stimulation
from existing proteins. This eliminates potentially pathogenic proteins as the cell attempts to
return to normal homeostasis after IFN" stressed" conditions. However, the molecular events …