Attenuated adipose tissue and skeletal muscle inflammation in obese mice with combined CD4+ and CD8+ T cell deficiency
IM Khan, XY Dai Perrard, JL Perrard, A Mansoori… - Atherosclerosis, 2014 - Elsevier
Objectives High-fat diet (HFD) feeding in mice is characterized by accumulation of αβ T cells
in adipose tissue. However, the contribution of αβ T cells to obesity-induced inflammation of
skeletal muscle, a major organ of glucose uptake, is unknown. This study was undertaken to
evaluate the effect of αβ T cells on insulin sensitivity and inflammatory state of skeletal
muscle and adipose tissue in obesity. Furthermore, we investigated whether CD4+
IFNγ+(TH 1) cells are involved in skeletal muscle and adipose tissue metabolic dysfunction …
in adipose tissue. However, the contribution of αβ T cells to obesity-induced inflammation of
skeletal muscle, a major organ of glucose uptake, is unknown. This study was undertaken to
evaluate the effect of αβ T cells on insulin sensitivity and inflammatory state of skeletal
muscle and adipose tissue in obesity. Furthermore, we investigated whether CD4+
IFNγ+(TH 1) cells are involved in skeletal muscle and adipose tissue metabolic dysfunction …