Temporal and spatial distribution of gentamicin in the peripheral vestibular system after transtympanic administration in guinea pigs
R Zhang, YB Zhang, CF Dai, PS Steyger - Hearing research, 2013 - Elsevier
BACKGROUND AND OBJECTIVE: Transtympanic administration of gentamicin is effective
for treating patients with intractable vertigo. This study explored the spatial and temporal
distribution of gentamicin in vestibular end-organs after transtympanic administration.
METHODS: Thirty guinea pigs were transtympanically injected with gentamicin conjugated
to Texas Red (GTTR) and their vestibular end-organs examined after various survival
periods. Another 9 guinea pigs received GTTR at different doses. Nine animals received …
for treating patients with intractable vertigo. This study explored the spatial and temporal
distribution of gentamicin in vestibular end-organs after transtympanic administration.
METHODS: Thirty guinea pigs were transtympanically injected with gentamicin conjugated
to Texas Red (GTTR) and their vestibular end-organs examined after various survival
periods. Another 9 guinea pigs received GTTR at different doses. Nine animals received …