Molecular basis of maillard amide-advanced glycation end product (AGE) formation in vivo
C Henning, M Smuda, M Girndt, C Ulrich… - Journal of Biological …, 2011 - ASBMB
The Maillard reaction in vivo entails alteration of proteins or free amino acids by non-
enzymatic glycation or glycoxidation. The resulting modifications are called advanced
glycation end products (AGEs) and play a prominent role in various pathologies, including
normoglycemic uremia. Recently, we established a new class of lysine amide modifications
in vitro. Now, human plasma levels of the novel amide-AGEs N 6-acetyl lysine, N 6-formyl
lysine, N 6-lactoyl lysine, and N 6-glycerinyl lysine were determined by means of LC-MS/MS …
enzymatic glycation or glycoxidation. The resulting modifications are called advanced
glycation end products (AGEs) and play a prominent role in various pathologies, including
normoglycemic uremia. Recently, we established a new class of lysine amide modifications
in vitro. Now, human plasma levels of the novel amide-AGEs N 6-acetyl lysine, N 6-formyl
lysine, N 6-lactoyl lysine, and N 6-glycerinyl lysine were determined by means of LC-MS/MS …