Is the presence of 6 or fewer crypt apoptotic bodies sufficient for diagnosis of graft versus host disease? A decade of experience at a single institution
J Lin, R Fan, Z Zhao, OW Cummings… - The American journal of …, 2013 - journals.lww.com
Histopathology assessment is crucial for the diagnosis of graft versus host disease (GVHD),
as the presence of crypt apoptosis is the cardinal criterion required. However, crypt
apoptosis is not limited to GVHD; it also occurs in other conditions such as infection, drug
reaction, or inflammatory reactions unrelated to GVHD. To better determine whether the
presence of 6 or fewer apoptotic bodies is sufficient for the diagnosis of GVHD, we
retrospectively reviewed 78 colon biopsies from 66 patients who received either …
as the presence of crypt apoptosis is the cardinal criterion required. However, crypt
apoptosis is not limited to GVHD; it also occurs in other conditions such as infection, drug
reaction, or inflammatory reactions unrelated to GVHD. To better determine whether the
presence of 6 or fewer apoptotic bodies is sufficient for the diagnosis of GVHD, we
retrospectively reviewed 78 colon biopsies from 66 patients who received either …