Mechanisms of bicarbonate secretion: lessons from the airways
RJ Bridges - Cold Spring Harbor Perspectives in …, 2012 - perspectivesinmedicine.cshlp.org
RJ Bridges
Cold Spring Harbor Perspectives in Medicine, 2012•perspectivesinmedicine.cshlp.orgEarly studies showed that airway cells secrete HCO3− in response to cAMP-mediated
agonists and HCO3− secretion was impaired in cystic fibrosis (CF). Studies with Calu-3
cells, an airway serous model with high expression of CFTR, also show the secretion of
HCO3− when cells are stimulated with cAMP-mediated agonists. Activation of basolateral
membrane hIK-1 K+ channels inhibits HCO3− secretion and stimulates Cl− secretion. CFTR
mediates the exit of both HCO3− and Cl− across the apical membrane. Entry of HCO3− on a …
agonists and HCO3− secretion was impaired in cystic fibrosis (CF). Studies with Calu-3
cells, an airway serous model with high expression of CFTR, also show the secretion of
HCO3− when cells are stimulated with cAMP-mediated agonists. Activation of basolateral
membrane hIK-1 K+ channels inhibits HCO3− secretion and stimulates Cl− secretion. CFTR
mediates the exit of both HCO3− and Cl− across the apical membrane. Entry of HCO3− on a …
Early studies showed that airway cells secrete HCO3− in response to cAMP-mediated agonists and HCO3− secretion was impaired in cystic fibrosis (CF). Studies with Calu-3 cells, an airway serous model with high expression of CFTR, also show the secretion of HCO3− when cells are stimulated with cAMP-mediated agonists. Activation of basolateral membrane hIK-1 K+ channels inhibits HCO3− secretion and stimulates Cl− secretion. CFTR mediates the exit of both HCO3− and Cl− across the apical membrane. Entry of HCO3− on a basolateral membrane NBC or Cl− on the NKCC determines which anion is secreted. Switching between these two secreted anions is determined by the activity of hIK-1 K+ channels.
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