Clinical validation of the FLIP algorithm and the SAF score in patients with non-alcoholic fatty liver disease
F Nascimbeni, P Bedossa, L Fedchuk, R Pais… - Journal of …, 2020 - Elsevier
Background & Aims Histological classifications used to diagnose/stage non-alcoholic fatty
liver disease (NAFLD) are based on morphology, with undetermined clinical correlates and
relevance. We assessed the clinical relevance of the fatty liver inhibition of progression
(FLIP) algorithm and the steatosis, activity, and fibrosis (SAF) scoring system. Methods One
hundred and forty consecutive patients with suspected NAFLD and a separate validation
cohort of 78 patients enrolled in a therapeutic trial, all with central reading of liver biopsy …
liver disease (NAFLD) are based on morphology, with undetermined clinical correlates and
relevance. We assessed the clinical relevance of the fatty liver inhibition of progression
(FLIP) algorithm and the steatosis, activity, and fibrosis (SAF) scoring system. Methods One
hundred and forty consecutive patients with suspected NAFLD and a separate validation
cohort of 78 patients enrolled in a therapeutic trial, all with central reading of liver biopsy …
