Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress
BACKGROUND: Severe asthma is characterized by persistent airway inflammation and
increased formation of reactive oxygen species. OBJECTIVES: Glutathione (GSH) is an
important antioxidant in the epithelial lining fluid (ELF). We hypothesized that airway GSH
homeostasis was altered in children with severe asthma and was characterized by
decreased GSH and increased glutathione disulfide (GSSG) concentrations. METHODS:
Bronchoalveolar lavage was obtained from 65 children with severe asthma, including 35 …
increased formation of reactive oxygen species. OBJECTIVES: Glutathione (GSH) is an
important antioxidant in the epithelial lining fluid (ELF). We hypothesized that airway GSH
homeostasis was altered in children with severe asthma and was characterized by
decreased GSH and increased glutathione disulfide (GSSG) concentrations. METHODS:
Bronchoalveolar lavage was obtained from 65 children with severe asthma, including 35 …
