[HTML][HTML] The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells
S Sahni, DH Bae, DJR Lane, Z Kovacevic… - Journal of Biological …, 2014 - ASBMB
N-myc downstream regulated gene 1 (NDRG1) is a potent metastasis suppressor with an
undefined role in the stress response. Autophagy is a pro-survival pathway and can be
regulated via the protein kinase-like endoplasmic reticulum kinase (PERK)/eIF2α-mediated
endoplasmic reticulum (ER) stress pathway. Hence, we investigated the role of NDRG1 in
stress-induced autophagy as a mechanism of inhibiting metastasis via the induction of
apoptosis. As thiosemicarbazone chelators induce stress and up-regulate NDRG1 to inhibit …
undefined role in the stress response. Autophagy is a pro-survival pathway and can be
regulated via the protein kinase-like endoplasmic reticulum kinase (PERK)/eIF2α-mediated
endoplasmic reticulum (ER) stress pathway. Hence, we investigated the role of NDRG1 in
stress-induced autophagy as a mechanism of inhibiting metastasis via the induction of
apoptosis. As thiosemicarbazone chelators induce stress and up-regulate NDRG1 to inhibit …