LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury
B Ji, M Li, WT Wu, LW Yick, X Lee, Z Shao… - Molecular and Cellular …, 2006 - Elsevier
LINGO-1 is a CNS-specific protein and a functional component of the NgR1/p75/LINGO-1
and NgR1/TAJ (TROY)/LINGO-1 signaling complexes that mediate inhibition of axonal
outgrowth. These receptor complexes mediate the axonal growth inhibitory effects of Nogo,
myelin-associated glycoprotein (MAG) and oligodendrocyte-myelin glycoprotein (OMgp) via
RhoA activation. Soluble LINGO-1 (LINGO-1-Fc), which acts as an antagonist of these
pathways by blocking LINGO-1 binding to NgR1, was administered to rats after dorsal or …
and NgR1/TAJ (TROY)/LINGO-1 signaling complexes that mediate inhibition of axonal
outgrowth. These receptor complexes mediate the axonal growth inhibitory effects of Nogo,
myelin-associated glycoprotein (MAG) and oligodendrocyte-myelin glycoprotein (OMgp) via
RhoA activation. Soluble LINGO-1 (LINGO-1-Fc), which acts as an antagonist of these
pathways by blocking LINGO-1 binding to NgR1, was administered to rats after dorsal or …