[HTML][HTML] Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1
T Yamazaki, E Sasaki, C Kakinuma, T Yano… - Journal of Biological …, 2005 - ASBMB
Acyl-CoA: diacylglycerol acyltransferases (DGATs) catalyze the last step in triglyceride (TG)
synthesis. The genes for two DGAT enzymes, DGAT1 and DGAT2, have been identified. To
examine the roles of liver DGAT1 and DGAT2 in TG synthesis and very low density
lipoprotein (VLDL) secretion, liver DGAT1-and DGAT2-overexpressing mice were created by
adenovirus-mediated gene transfection. DGAT1-overexpressing mice had markedly
increased DGAT activity in the presence of the permeabilizing agent alamethicin. This …
synthesis. The genes for two DGAT enzymes, DGAT1 and DGAT2, have been identified. To
examine the roles of liver DGAT1 and DGAT2 in TG synthesis and very low density
lipoprotein (VLDL) secretion, liver DGAT1-and DGAT2-overexpressing mice were created by
adenovirus-mediated gene transfection. DGAT1-overexpressing mice had markedly
increased DGAT activity in the presence of the permeabilizing agent alamethicin. This …